The show, named after the song "I'd Do Anything", was hosted by Graham Norton with Andrew Lloyd Webber again overseeing the programme, together with theatrical producer Cameron Mackintosh. In January 2008, John Barrowman confirmed he would be taking part in the show. The BBC also confirmed in late February 2008 that Barry Humphries would join Barrowman and Denise Van Outen (who was previously the presenter of the US Broadway reality show Grease: You're the One that I Want!) on the judging panel of the show.
Auditions for the show began in January 2008, with the show airing on BBC One throughout March, April and May 2008. In the final, on 31 May, Jodie Prenger was announced as the winner of the series.